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The Diabetes Educator
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*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*CHOLESTEROL
Medline Plus Health Information
*Diabetes Complications
*Statins
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FEATURES

Do People With Diabetes Need Statins?

John R. White, Jr, PharmD

From the Department of Pharmacotherapy, College of Pharmacy, Washington State University, Spokane, Washington.

Correspondence to John R. White Jr, PharmD, Department of Pharmacotherapy, Washington State University Spokane, 412 E. Spokane Falls Boulevard, Spokane, WA 99202 (whitej{at}wsu.edu).

The prevalence of type 2 diabetes mellitus continues to increase rapidly. Persons with diabetes face a 2-fold greater absolute risk of cardiovascular disease (CVD) than those without diabetes. Many diabetic patients die before reaching the hospital after a cardiovascular event. Use of statin therapy for intensive control of diabetic dyslipidemia has produced relative reductions in CVD risk of about 25% in randomized, controlled clinical trials. This is true even though low-density lipoprotein cholesterol, the primary target of statin therapy, might not be markedly elevated in diabetic patients. Most patients with diabetes or diabetes plus established CVD warrant intensive statin therapy. Statin therapy has the ability to achieve low-density lipoprotein cholesterol goals recommended in treatment guidelines. Alone or in combination with an additional lipid-lowering drug, statins may also improve triglyceride and high-density lipoprotein cholesterol abnormalities in patients with diabetes.

The Diabetes Educator, Vol. 34, No. 4, 664-673 (2008)
DOI: 10.1177/0145721708320919
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